Interested

• ions
• metal ions
• peptide
• metal coordination
• inorganic nuclear chemistry
• binding affinity
• metal binding sites
• histidine rich
• antimicrobial activity
• stability

Scientific discipline

• chemical sciences

Latest publications

• Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides.
• CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
• Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides
• Impact of metal coordination and pH on the antimicrobial activity of histatin 5 and the products of its hydrolysis
• Insights into the Chemistry, Structure, and Biological Activity of Human Salivary MUC7 Fragments and Their Cu(II) and Zn(II) Complexes
• A comparative study on nickel binding to Hpn-like polypeptides from two Helicobacter pylori strains
• Zn(II) Induces Fibril Formation and Antifungal Activity in Shepherin I, An Antimicrobial Peptide from Capsella bursa-pastoris
• Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity
• Metal coordination to solute binding proteins – exciting chemistry with potential biological meaning
• Zn(II) coordination influences the secondary structure, but not antimicrobial activity of the N-terminal histatin 3 hydrolysis product
• Phytochelatins Bind Zn(II) with Micro- to Picomolar Affinities without the Formation of Binuclear Complexes, Exhibiting Zinc Buffering and Muffling Rather than Storing Functions
• Phytochelatins as a dynamic system for Cd(II) buffering from the micro- to femtomolar range.
• Uncapping the N-terminus of a ubiquitous His-tag peptide enhances its Cu²⁺ binding affinity.
• Copper(II)-binding induces a unique polyproline type II helical structure within the ion-binding segment in the intrinsically disordered F-domain of ecdysteroid receptor from Aedes aegypti.
• Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans?
• Zinc(II)—the overlooked éminence grise of chloroquine’s fight against COVID-19?
• Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules.
• The intrinsically disordered C-terminal F domain of the ecdysteroid receptor from Aedes aegypti exhibits metal ion-binding ability.
• Mono-substituted cage-like silsesquioxanes bound by trifunctional acyl chloride as a multi-donor N,O-type ligand in copper(II) coordination chemistry: synthesis and structural properties.
• Poly-Xaa sequences in proteins - biological role and interactions with metal ions : chemical and medical aspects.